Circulating Tumor Cells Shielded with Extracellular Vesicle-Derived CD45 Evade T Cell Attack to Enable Metastasis

The authors unequivocally identified a subpopulation of circulating tumor cells (CTCs) shielded with extracellular vesicle-derived CD45 that resisted T cell attack. A higher percentage of CD45+ CTCs was found to be closely correlated with higher incidence of metastasis and worse prognosis in cancer patients.