Proteinase 3 Depletion Attenuates Leukemia by Promoting Myeloid Differentiation

Researchers showed that the genetic elimination of proteinase 3 (PRTN3) in mice led to spontaneous myeloid differentiation. Mechanistically, their findings indicated that PRTN3 interacted with the N-terminal of STAT3, serving as a negative regulator of STAT3-dependent myeloid differentiation.