Oncogene-Driven Non-Small Cell Lung Cancers in Patients with a History of Smoking Lack Smoking-Induced Mutations

To better understand the clonal architecture and genomic landscape of non-smoking-related oncogene-driven tumors in smokers compared to typical-smoking NSCLCs, scientists investigated genomic and transcriptomic alterations in 173 tumor sectors from 48 NSCLC patients.