Sprouty Genes Regulate Activated Fibroblasts in Mammary Epithelial Development and Breast Cancer

Investigators showed in mammary stromal fibroblasts that loss of the receptor tyrosine kinase (RTK) negative feedback regulators encoded by Spry1, Spry2, and Spry4 causes upregulation of signaling in multiple RTK pathways and increased extracellular matrix remodeling, resulting in accelerated epithelial branching.