Increased miR-3074-5p Expression Promotes M1 Polarization and Pyroptosis of Macrophages via ERα/NLRP3 Pathway and Induces Adverse Pregnancy Outcomes in Mice

Researchers found that litter size and fetal weight were significantly reduced, whereas the rate of embryo resorption was increased in miR-3074-5p knock-in (3074-KI) pregnant mice, compared to that of wild-type (WT) pregnant mice.