OTUD5 Promotes the Inflammatory Immune Response by Enhancing MyD88 Oligomerization and Myddosome Formation

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Researchers identified OTUD5 acted as an essential regulator for MyD88 oligomerization and Myddosome formation. OTUD5 directly interacted with MyD88 and cleaved its K11-linked polyubiquitin chains at Lys95, Lys231 and Lys250.
[Cell Death & Differentiation]
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