OTUD5 Promotes the Inflammatory Immune Response by Enhancing MyD88 Oligomerization and Myddosome Formation

Researchers identified OTUD5 acted as an essential regulator for MyD88 oligomerization and Myddosome formation. OTUD5 directly interacted with MyD88 and cleaved its K11-linked polyubiquitin chains at Lys95, Lys231 and Lys250.