Thiamine-Modified Metabolic Reprogramming of Human Pluripotent Stem Cell-Derived Cardiomyocyte under Space Microgravity

Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) subjected to space microgravity showed decreased beating rate and abnormal intracellular calcium cycling. Metabolomic and transcriptomic analyses revealed a battery of metabolic remodeling of hPSC-CMs in spaceflight, especially thiamine metabolism.