Inherited KDM6^AA649T Facilitates Tumor-Immune Escape and Exacerbates Colorectal Signet-Ring Cell Carcinoma Outcomes

Overexpression of lysine-specific demethylase 6A (KDM6)AA694T in colorectal signet-ring cell carcinoma (SRCC) cell line promoted cell proliferation, invasion and migration, which were further confirmed in vivo by constructing orthotopic tumor growth and lung metastasis models.