Single Cell Analysis Unveils B Cell-Dominated Immune Subtypes in HNSCC for Enhanced Prognostic and Therapeutic Stratification

Using single-cell RNA sequencing data from the Gene Expression Omnibus database, the study identified distinct gene expression patterns in tumor-infiltrating B cells (TIL-BAs). Head and neck squamous cell carcinoma samples were categorized into TIL-Bs inhibition and TIL-Bs activation groups using unsupervised clustering.