TEAD2 Initiates Ground-State Pluripotency by Mediating Chromatin Looping

The authors systematically screened factors essential for ESC pluripotency, identifying transcriptional enhanced associate domain (TEAD) 2 as an ancillary factor maintaining ground-state pluripotency in 2i/leukemia inhibitory factor (LIF) ESCs and facilitating the transition from serum/LIF to 2i/LIF ESCs.