A Highly Biocompatible CE-Crosslinked Collagen Implant with Exceptional Anti-calcification and Collagen Regeneration Capabilities for Aging Skin Rejuvenation

A novel collagen crosslinking agent (CE) was synthesized through a reaction involving chitosan quaternary ammonium salt with 1,4-butanediol diglycidyl ether. Compared to collagen crosslinked with glutaraldehyde, the CE-crosslinked collagen implant exhibited notable stability and durability.