Evaluation of EGFR and COX Pathway Inhibition in Human Colon Organoids of Serrated Polyposis and Other Hereditary Cancer Syndromes

Researchers examined the effects of EGFR and COX pathway inhibition in organoid cultures derived from uninvolved colon and polyps of serrated polyposis syndrome patients. They also compared with organoids representing the hereditary gastrointestinal syndromes, Familial Adenomatous Polyposis and Lynch syndrome.