Immunogenic Material Vaccine for Cancer Immunotherapy by Structure-Dependent Immune Cell Trafficking and Modulation

Scientists manipulated the immunopotentiator manganese into six differing structures that resemble the architectures of two types of pathogens. They revealed that innate immune cells accurately sense and respond to the architectures, of which two outperformed material candidates showedhigher competence in creating local pro-inflammatory environment with promoted innate immune cell influx and stimulatory effects on multiple subsets of dendritic cells.