Caspase 8 Deletion Causes Infection/Inflammation-Induced Bone Marrow Failure and MDS-Like Disease in Mice

Caspase 8 (Casp8) is a master regulator of pyroptosis, apoptosis, and necroptosis (PANoptosis). To study the role of PANoptosis in hematopoiesis, scientists generated inducible Casp8 knockout mice.