Tbl1 Promotes Wnt/β-Catenin Signaling-Induced Degradation of the Tcf7l1 Protein in Mouse ESCs

Investigators showed that the overexpression of transducin-β-like protein 1 (Tbl1) or its family member Tblr1 could decrease Tcf7l1 protein levels, while the knockdown of each increased Tcf7l1 levels without affecting Tcf7l1 transcription.