The pRb/RBL2-E2F1/4-GCN5 Axis Regulates Cancer Stem Cell Formation and G0 Phase Entry/Exit by Paracrine Mechanisms

Investigators used a quantitative proteomic approach for identifying secreted proteins of CSCs in pancreatic cancer. They uncovered that the cell-autonomous E2F1/4-pRb/RBL2 axis balanced non-cell-autonomous signaling in healthy ductal cells but became deregulated upon KRAS mutation.