METTL14 Downregulation Drives S100A4+ Monocyte-Derived Macrophages via MyD88/NF-κB Pathway to Promote MAFLD Progression

In vivo and in vitro mechanistic studies indicated that METTL14 downregulation decreased the level of GLS2 by affecting the translation efficiency mediated by YTHDF1 in an m6A-depedent manner, which might help to form an oxidative stress microenvironment and accordingly recruit Cx3cr1+Ccr2+ monocyte-derived macrophages.