Sclareol Protected against Intestinal Barrier Dysfunction Ameliorating Crohn’s Disease-Like Colitis via Nrf2/NF-B/MLCK Signaling

In vitro, a TNF-α-induced colonic organoid model was established to test the direct effect of sclareol on inflammation-induced intestinal barrier injury and inflammatory response. The Nrf2/NF-κB/MLCK signaling was analyzed to explore the mechanism of sclareo.