Metabolic Reprogramming of Tumor-Associated Macrophages Using Glutamine Antagonist JHU083 Drives Tumor Immunity in Myeloid-Rich Prostate and Bladder Cancer Tumors

Scientists showed JHU083-mediated glutamine antagonism in tumor microenvironments induced TNF, pro-inflammatory, and mTORC1 signaling in intratumoral tumor-associated macrophages clusters.