LGR6 Frameshift Variant Abrogates Receptor Expression on Select Leukocyte Subsets and Associates With Viral Infections

In neutrophils, monocytes, and natural killer cells from volunteers homozygous for this variant, investigators found a significant downregulation in the expression of leucine-rich repeat-containing G-protein-coupled receptor 6 (LGR6) when compared with controls without the variant.