Pretreatment with IL-15 and IL-18 Rescues Natural Killer Cells From Granzyme B-Mediated Apoptosis after Cryopreservation

Using CRISPR-Cas9 gene editing and confocal microscopy, investigators found that cryopreserved Natural Killer cells largely died via apoptosis initiated by leakage of granzyme B from cytotoxic vesicles.