An Intricate Regulatory Circuit between FLI1 and GATA1/GATA2/LDB1/ERG Dictates Erythroid vs. Megakaryocytic Differentiation

Using the megakaryocytic erythroid progenitor‑like cell line HEL western blotting, RT‑qPCR, lentivirus‑mediated downregulation, flow cytometry as well as chromatin immunoprecipitation assay demonstrated that the E26 transformation‑specific transcription factor friend leukemia integration factor 1 (Fli‑1) inhibited erythroid differentiation.