Targeting SOX13 Inhibits Assembly of Respiratory Chain Supercomplexes to Overcome Ferroptosis Resistance in Gastric Cancer

Investigators showed that SOX13 boosted protein remodeling of electron transport chain complexes by directly transactivating SCAF1. This led to increased supercomplex assembly, mitochondrial respiration, mitochondrial energetics and chemo- and immune-resistance.
[Nature Communications]
Full Article