Targeting SOX13 Inhibits Assembly of Respiratory Chain Supercomplexes to Overcome Ferroptosis Resistance in Gastric Cancer

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Investigators showed that SOX13 boosted protein remodeling of electron transport chain complexes by directly transactivating SCAF1. This led to increased supercomplex assembly, mitochondrial respiration, mitochondrial energetics and chemo- and immune-resistance.
[Nature Communications]
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