The Manganese Transporter SLC39A8 Links Alkaline Ceramidase 1 to Inflammatory Bowel Disease

Investigators generated Slc39a8 intestinal epithelial cell-specific-knockout mice, which displayed markedly decreased manganese (Mn) levels in blood and most organs. SLC39A8 was localized to the apical membrane and mediated 54 Mn uptake in intestinal organoid monolayer cultures.