XIST Dampens X Chromosome Activity in a SPEN-Dependent Manner during Early Human Development

The authors used hESCs in a naive state of pluripotency to assess the function of X-inactive specific transcript (XIST) and X-active coating transcript (XACT) in shaping the X chromosome chromatin and transcriptional landscapes during preimplantation development.
[Nature Structural & Molecular Biology]
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