Development of an Evaluation System Using Intestinal Organoids for Drug Efflux Transport Analysis by an Imaging Approach

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Researchers investigated the effects of passage and cryopreservation of enteroids, organoids derived from intestine. They focused on P-glycoprotein (p-gp) and compared the transfer rates of rhodamine 123 into the lumen of enteroids with and without a P-gp inhibitor.
[Journal of Pharmaceutical Sciences]
AbstractGraphical Abstract