Development of an Evaluation System Using Intestinal Organoids for Drug Efflux Transport Analysis by an Imaging Approach

Researchers investigated the effects of passage and cryopreservation of enteroids, organoids derived from intestine. They focused on P-glycoprotein (p-gp) and compared the transfer rates of rhodamine 123 into the lumen of enteroids with and without a P-gp inhibitor.
[Journal of Pharmaceutical Sciences]
AbstractGraphical Abstract