SETD3 Is a Mechanosensitive Enzyme That Methylates Actin on His-73 to Regulate Mitochondrial Dynamics and Function

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Scientists showed that SET domain protein 3 (SETD3), a recently described actin histidine methyltransferase, directly methylates actin Histidine-73 and enhances F-actin polymerization on mitochondria.
[Journal of Cell Science]
Abstract