In Vitro and In Vivo Inhibition of the Host TRPC4 Channel Attenuates Zika Virus Infection

Researchers investigated whether TRPCs might be involved in the pathogenesis of Zika virus (ZIKV) infection. They found that ZIKV infection increases TRPC4 expression in host cells via the interaction between the ZIKV-NS3 protein and CaMKII, enhancing TRPC4-mediated calcium influx.