Rejuvenation of BMSCs Senescence by Pharmacological Enhancement of TFEB-Mediated Autophagy Alleviates Aged-Related Bone Loss and Extends Lifespan in Middle Aged Mice

Researchers synthetized and demonstrated a novel autophagy activator, CXM102 that could induce autophagy in aged bone marrow bone marrow (B) MSCs, resulting in rejuvenation and preferential differentiation into osteoblasts of BMSCs