Stearoyl-CoA Desaturase Inhibition Is Toxic to Acute Myeloid Leukemia Displaying High Levels of the De Novo Fatty Acid Biosynthesis and Desaturation

Researchers identified stearoyl-CoA desaturase (SCD), the key enzyme in fatty acid desaturation, as prognostic of patients’ outcomes and, using the clinical-grade inhibitor SSI-4, show that SCD inhibition is a therapeutic vulnerability across multiple AML models in vitro and in vivo.