Chromosome Instability Functions as a Potential Therapeutic Reference by Enhancing Chemosensitivity to BCL-XL Inhibitors in Colorectal Carcinoma

By using machine learning methods, researchers screened out two BCL-XL inhibitors Navitoclax and WEHI-539 as chromosome instability-sensitive (CIN) reagents in colorectal cancer (CRC). Subsequent analyses using a CIN-aneuploidy cell model confirmed the vulnerability of high-CIN CRC cells to these drugs.