PD-1 Signaling Limits Expression of Phospholipid Phosphatase 1 and Promotes Intratumoral CD8⁺ T Cell Ferroptosis

Researchers examined the impact of the tumor microenvironment on phospholipid metabolism in CD8+ T cells. In lung cancer, phosphatidylcholine and phosphatidylethanolamine were lower in intratumoral CD8+ T cells than in circulating CD8+ T cells.