HLA A*24:02–Restricted T Cell Receptors Cross-Recognize Bacterial and Preproinsulin Peptides in Type 1 Diabetes

Combinatorial peptide library screening was used to produce a preferred peptide recognition landscape for a patient-derived T cell receptor that recognized the preproinsulin-derived peptide sequence LWMRLLPLL in the context of disease risk allele HLA A*24:02.