Bifidobacterium pseudolongum-Derived Bile Acid from Dietary Carvacrol and Thymol Supplementation Attenuates Colitis via cGMP-PKG-mTORC1 Pathway

Investigators uncovered a novel regulatory mechanism where hyodeoxycholic acid and 12-ketodeoxycholic acid inhibited colonic inflammation by reducing the expression of transmembrane guanylate cyclase 1A in the colonic epithelium.