Cellular Taxonomy of the Preleukemic Bone Marrow Niche of Acute Myeloid Leukemia

Using our AML-murine model, researchers performed single-cell RNA-sequencing of preleukemic BMM cells. They found normal HSC-regulating LepR+ mesenchymal stem cells, and endothelial cells were decreased, along with increases in CD55+ fibroblasts and pericytes.