Targeting Unc5b in Macrophages Drives Atherosclerosis Regression and Pro-Resolving Immune Cell Function

Investigators tested the therapeutic potential of deleting Unc5b in mice with advanced atherosclerosis. They generated Unc5bfl/flCx3cr1creERT2/WT mice, which allowed conditional deletion of Un5b in monocytes and macrophages by tamoxifen injection.