Development of iPSC-Derived Human Bone Marrow Organoid for Autonomous Hematopoiesis and Patient-Derived HSPC Engraftment

Researchers developed an iPSC-derived human bone marrow organoid model that closely replicated the bone marrow microenvironment, facilitating the engraftment of myelodysplastic syndrome patient-derived hematopoietic stem and progenitor cells.