Inhibition of Glutaminase Elicits Senolysis in Therapy-Induced Senescent Melanoma Cells

Scientists demonstrated that glutaminase 1 (GLS1) expression was specifically upregulated in cyclin D1-cyclin-dependent kinases 4 and 6 small molecule inhibitor-induced senescent BrafV600E melanoma cells. Upregulated GLS1 expression rendered BrafV600E melanoma senescent cells vulnerable to GLS1 inhibitor.