Exploiting Mitochondria by Triggering a Faulty Unfolded Protein Response Leads to Effective Cardioprotection

Scientists investigated the role of Fundc1 in cardiac protection under high-altitude hypoxic conditions and elucidated its underlying molecular mechanisms. Using cardiomyocyte-specific Fundc1 knockout mice, they demonstrated that Fundc1 deficiency exacerbated cardiac dysfunction under simulated high-altitude hypoxia, manifesting as impaired systolic and diastolic function.