S1PR3-Driven Positive Feedback Loop Sustains STAT3 Activation and Keratinocyte Hyperproliferation in Psoriasis

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The authors identifed sphingosine-1-phosphate receptor 3 (S1PR3) as a critical regulator of STAT3 activation and psoriasis pathogenesis, orchestrating a self-amplifying circuit that sustained keratinocyte hyperproliferation and chronic inflammation.
[Cell Death & Disease]
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