Intercellular mRNA Transfer Alters the Human Pluripotent Stem Cell State

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Researchers uncovered an intercellular mRNA transfer phenomenon that allowed for the adaptation and reprogramming of human primed pluripotent stem cells (hPSCs). This process was induced by the direct cell contact-mediated coculture with mouse ESCs under the condition impermissible for primed hPSC culture.
[Proceedings of The National Academy of Sciences of The United States of America]
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