A Skin Organoid-Based Infection Platform Identifies an Inhibitor Specific for HFMD

Scientists used hiPSC-derived skin organoids as a model for EV-A71 infection and found that multiple cell types within the skin organoids, including epidermal cells, hair follicle cells, fibroblasts, and nerve cells, expressed EV-A71 receptors and were susceptible to EV-A71 infection.