Newsletters

[Science] Investigators described an intranasal liposomal formulation combining toll-like receptor 4 and 7/8 ligands with a model antigen, ovalbumin, that provided broad, durable protection in mice for at least 3 months against infection with SARS-CoV-2 and Staphylococcus aureus.

[Bone Marrow Transplantation] The authors explore key insights gained from hematologic applications of CAR T cells and T cell engagers, and discuss how these lessons can guide the clinical use of these therapies in autoimmune diseases.

[Nature Aging] Scientists identified defects in dendritic cell (DC) migration during aging, alongside a dysfunction-associated gene signature in migratory DCs, and implicated these defects in the diminished vaccine response observed in aging.

[Nature Reviews Cardiology] The authors summarize the mechanisms, epidemiology and management of T cell therapy-associated cytokine release syndrome and subsequent cardiotoxicity.

[Nature Chemical Biology] Scientists combined rational design and library-based optimization of a protein–protein interaction (PPI) of human origin to develop venetoclax-controlled drug-regulated off-switch PPI -CARs.

[Nature] Cryo-electron microscopy structures of deoxynucleoside triphosphohydrolase enzyme in activated and suppressed states reveal how dTTP and p3diT control distinct allosteric sites and regulate effector function.

[Iscience] Researchers hypothesized that T cells determine the healing of Achilles tendons after acute rupture and can be used as prognostic indicator of healing outcomes.

[Science] Investigators reported that transcription factor Etv3 was preferentially expressed in mature dendritic cells (DCs), including tissue-derived migratory DCs, and facilitates their homeostatic maturation and CCR7-dependent migration.

[Nature Communications] The authors identify ETS homologous factor (EHF) as a transcription factor that regulates conventional dendritic cell maturation and immunosuppression after TLR7/8/9 stimulation.

[Nature Communications] The authors identified a cis transcriptional regulatory element that distinguishes RORγt+ antigen-presenting cells from other of RORγt+ cell types.

[Advanced Healthcare Materials] Researchers developed an in vitro cardiac inflammation model that enables controlled investigation of macrophage-cardiomyocyte interactions.

[European Journal of Pharmacology] Investigators demonstrated that empagliflozin reduced the incidence of ventricular arrhythmia by regulating AMPK/mTOR signaling and restored autophagic flux in DOX-treated rats and neonatal rat ventricular cardiomyocytes.