SARS-CoV-2 Infection during the First Trimester Leads to Profound Immune Dysregulation at the Maternal-Fetal Interface despite Limited Virus Detection in Placental Tissues

Researchers identified infrequent instances of SARS-CoV-2 infection in both villous and decidual tissues. Bulk and single-cell transcriptomic analyses revealed pronounced, cell type-specific antiviral and immune responses within the placental microenvironment.