Combined Mesenchymal Stem Cells and Metformin Therapy Modulates Key Macromolecular Pathways in Pulmonary Fibrosis Based on Evidence from Untargeted Metabolomics

Investigators treated bleomycin-induced pulmonary fibrosis in rats with MSCs, metformin, or their combination. Combination therapy most effectively corrected metabolic disruptions and attenuated fibrotic remodeling.