Newsletters

[Cornell Chronicle] Five innovative immunology research projects have been selected for funding through the Cornell Center for Immunology's 2026 Multidisciplinary Seed Grants.

[University of Colorado Anschutz Cancer Center] Dr. Siddhartha Mitra recently received a three-year grant to develop chimeric antigen receptor (CAR) macrophages therapies to treat diffuse midline gliomas, a particularly deadly type of pediatric brain cancer.

[American Journal of Respiratory and Critical Care Medicine] Scientists characterized the differences in composition of the immune cells in the alveolar space of patients with chronic obstructive pulmonary disease versus healthy controls and the relation with severity of airflow limitation at a single cell resolution.

[Clinical Cancer Research] In the randomized Phase III clinical trial, TIL therapy improved progression-free survival compared with ipilimumab in patients with unresectable cutaneous melanoma. They established autologous tumor cell lines from 24 patients and assessed the anti-tumor reactivity of the infused T cells through co-culture assays and intracellular cytokine staining.

[Immunology and Cell Biology] Investigators developed the T cell momentum assay, a quantitative functional profiling platform combining standardized T cell activation with defined stimulus withdrawal to measure proliferation, survival, and activation dynamics over time.

[Science Advances] Scientists investigated the tissue-resident CD4 T cell compartment across donor-matched lymphoid and nonlymphoid tissues and uncovered a population enriched primarily in the ileum and liver displaying a rich polyfunctional profile with diverse T helper 1/17/22 characteristics.

[Cell Discovery] Researchers constructed a pan-cancer atlas comprising 28 TAMs by integrating single-cell transcriptomic and spatial transcriptomic data from 291 human samples across 16 cancer types. They elucidated the biological characteristics and of these subtypes within the TME as well as the interaction mechanisms between TAMs and TME components associated with tumor progression.

[Microbiome] Scientists investigated the role of the gut microbiota in IgA deficiency and its potential in promoting IgA induction in children with respiratory tract infections. A Bifidobacterium-dominated community cluster was linked to stronger IgA responses in stool, serum, and lung.

[Cellular & Molecular Immunology] Scientists focus on recent research that highlights how B cell heterogeneity influences anti-cancer immunity and how this knowledge could be harnessed to develop B cell-based immunotherapies and to fully utilize the power of antibody-based cancer diagnosis and patient stratification.

[Cell Host & Microbe] Researchers discovered that maternal helminths, an evolutionarily conserved mammalian partner lost in industrialized societies, confer broad and lasting protection against respiratory viruses in offspring. Analysis of chronically helminth-infected human populations reveals gut microbiota enriched for tryptophan metabolic capacity.

[Cancer Cell] The authors synthesize emerging data highlighting tumor indications suitable to investigate personalized cancer neoantigen vaccines, define optimal clinical settings for vaccine administration, and discuss combinatorial regimens to enhance efficacy, as well as the timing and sequencing in multimodal treatment.

[Molecular Cancer] Scientists summarize the patterns of T cell fate transformation during tumor development and provides an in-depth analysis of the essential characteristics of T cell intoxication and betrayal, including their phenotypic features, functional alterations, and their impact on the tumor microenvironment and immunotherapy.