Newsletters

[Karolinska Institutet] Karolinska Institutet has received a grant of DKK 10 million (approximately SEK 15 million) from the Novo Nordisk Foundation for research on cell therapy for Parkinson’s disease. The project is led by Johan Ericson, professor at the Department of Cell and Molecular Biology.

[Nature Communications] Researchers focused on the understudied paralogs of the U1 small nuclear RNA gene known as variant U1 snRNAs. By generating isogenic knockout lines of hiPSCs for different variant U1s, they showed that their loss profoundly changes both gene expression and cell cycle profiles.

[Proceedings of the National Academy of Sciences of the United States of America] Using inflation–deflation assays and high-resolution imaging, scientists found that these fluid-filled shells are weakly pressurized and achieve extreme deformability through reversible soft modes of deformation accommodated by the cytoskeleton.

[Journal for Immunotherapy of Cancer] Researchers developed a feeder-free differentiation platform to generate CD1c⁺CD141⁺ hPSC-derived conventional dendritic cells (DCs) to provide a scalable source of DCs with defined properties.

[Cell & Bioscience] Investigators expanded the understanding of the molecular regulatory network underlying hPSC self-renewal maintenance and validates ESRG as a promising target for improving the in vitro expansion of hPSCs.

[Stem Cell Reports] Using isogenic hESC models carrying three patient-derived MECP2 mutations, scientists followed the transcriptome from pluripotency through neuroectoderm, neural stem/progenitor stages.

[International Journal of Stem Cells] The authors introduced O-cyclic phytosphingosine-1-phosphate (cP1P), a novel culture additive structurally analogous to S1P, which markedly enhances hPSC self-renewal and survival.

[Trends in Biotechnology] Scientists discuss how combining iPSC-derived organoids with automation is poised to transform disease modeling and drug development.

[Bioscience Reports] The authors discuss recent insights into the mechanisms contributing to neurodegenerative disease that have been gained specifically from modelling neuron–glia interactions in human iPSCs.

[ACS Nano] To modulate the oxidative microenvironment and remodel the ECM, a smart microneedle capable of regulating reactive oxygen species and delivering matrix metalloproteinase functions was developed.

[Genome Medicine] This human multi-omics study defines diabetic cardiomyopathy by the concurrent dysregulation of cardiac fuel metabolism, mitochondrial quality control, and matrix remodeling, offering novel mechanistic insights and highlighting acyl-CoA synthetase long-chain family member 1 and BNIP3L as potential therapeutic targets for diabetes-associated cardiac dysfunction.

[Cancer Research] Researchers identified LRRC15⁺ cancer-associated fibroblasts (CAFs) as a tumor-specific CAF subset in lung cancer and proposed LRRC15 as a potential therapeutic target.