Runx3 Instructs Aire mTEC Development, TSA Gene Expression, and Central Tolerance

Researchers uncovered new functions for Runx3 in thymic epithelial lineage development and showed Runx3 expression in medullary thymic epithelial cells (mTECs) is required for both Autoimmune Regulator + (Aire+) mTEC development and tissue-specific antigen (TSA) gene expression.