Newsletters

[Nature Metabolism] Researchers discovered that deleting the cardiolipin-synthesizing enzyme protein tyrosine phosphatase mitochondrial 1 (PTPMT1) in T cells predisposes mice to colitis due to impaired Treg cell function in the absence of dysbiosis.

[Immunology] The authors review preclinical and clinical applications of Treg-based therapies, including adoptive Treg transfer, low-dose IL-2, and CAR-Treg therapy. They discuss their effectiveness in modulating immune responses across diverse pathological contexts.

[Clinical Reviews in Allergy & Immunology] Scientists dissect the multi-layered mechanisms through which dendritic cells orchestrate immune tolerance, spanning cytokine signaling, metabolic reprogramming, epigenetic remodeling, and migratory dynamics.

[Nature Communications] Using a Treg-specific chaperone-mediated autophagy (CMA)-deficient mouse model, scientists showed that CMA is crucial for maintenance of peripheral tolerance by Tregs. Mice with CMA-defective Tregs display signs of chronic inflammation, which results in reduced survival as they age.

[Journal of Autoimmunity] Researchers uncovered new functions for Runx3 in thymic epithelial lineage development and showed Runx3 expression in medullary thymic epithelial cells (mTECs) is required for both Autoimmune Regulator + (Aire+) mTEC development and tissue-specific antigen (TSA) gene expression.

[Science Advances] Investigators identified a positive correlation between the expression of Dhx9, a nuclear helicase, and TH17 lineage during the progression of autoimmune diseases.

[Immunity] Scientists showed that the master regulator Foxp3 cooperates with BATF to direct cis-regulatory programs and gene expression essential for the differentiation of immunosuppressive effector Treg cells.

[Coya Therapeutics, Inc.] Coya Therapeutics, Inc. announced that the US FDA has granted Fast Track Designation for COYA 302, an investigational biologic combination therapy with a dual mechanism of action, for the treatment of amyotrophic lateral sclerosis (ALS).

[Advanced Science] Scientists found that endothelial cells (ECs) upregulate the transcription factor YY1 during post-ischemic vascular regeneration, but this response is blunted in diabetic ECs. They identifited endothelial YY1 as a mediator through which CD4+ Tregs drive angiogenesis in non-diabetic condition.

[Molecular Cancer] The authors propose the Treg-cell death axis as a unifying framework linking immune tolerance, regulated cell death, and immunotherapy resistance in lung cancer. Targeting this axis through may provide opportunities to overcome therapeutic resistance and improve clinical outcomes.

[Gut] Researchers examined the role of interferon-stimulated gene 15 (ISG15) in the activation of hepatic stellate cells and liver fibrosis.

[Blood] Investigators generated transferrin receptor (Tfr)c^Alb-Cre;Tfr2^Alb-Cre mice with hepatocyte-specific ablation of both Tfr1 and Tfr2 to study their effects on iron homeostasis.