A Kinetics-Based Model of Haematopoiesis Reveals Extrinsic Regulation of Skewed Lineage Output from Stem Cells

By performing single-cell transplantations of over 1,000 highly purified murine long-term HSCs combined with in-depth phenotyping of their clonal progeny, scientists defined kinetics-based reconstitution parameters which aligned HSCs into a single hierarchical trajectory reflective of functional potency.